Berceanu Sabina, Pătraşcu Anca, Berceanu C, Tica A A, Bădulescu Adriana, Brăila M B, Simionescu Cristiana
Department of Obstetrics and Gynecology, University of Medicine and Pharmacy of Craiova, Craiova, Romania.
Rom J Morphol Embryol. 2008;49(1):47-52.
The Obstetrical Antiphospholipid Antibody Syndrome (OAAS) is representing a separate entity of the global Antiphospholipid Antibody Syndrome (APS), focusing the pregnancy morbidity. OAAS is generating morphopathological changes in almost all components of the gestational biologic transitory system (GBTS): placenta, umbilical cord or uterine wall. The most important, serious and lengthened anomalies are occuring in placenta. Our research has been developed on a group of 68 patients diagnosed with OAAS, initially using the Sapporo criteria and later using the "Sydney" ones. There have been morphopathologically examined: placenta, umbilical cord and myometrium. Histological examination revealed on one hand macroscopic modifications: fibrinoid deposits, white or red placental infarctions, intervillous thrombosis, marginal or basal decidual hematoma, calcareous deposits, umbilical cord thrombosis, and on the other hand microscopic findings: placental infarction, fibrinoid necrosis, myometrial thrombosis, degenerative myometrial disorders, focal myometrial necrosis, villous stasis and necrosis, umbilical cord thrombosis. Because of the increased prothrombotic background, in APS, any vessel or organ could be involved, with no exception for GBTS elements. The basis of the pregnancy morbidity from the obstetrical APS is represented by the morphopathological changes occurring in fetal adnexa and uterine structures.
产科抗磷脂抗体综合征（OAAS）是全球抗磷脂抗体综合征（APS）的一个独立实体，主要关注妊娠并发症。OAAS几乎会在妊娠生物过渡系统（GBTS）的所有组成部分中引发形态病理学变化：胎盘、脐带或子宫壁。最重要、最严重且持续时间最长的异常发生在胎盘。我们对一组68例被诊断为OAAS的患者进行了研究，最初采用札幌标准，后来采用“悉尼”标准。对胎盘、脐带和子宫肌层进行了形态病理学检查。组织学检查一方面揭示了宏观改变：纤维蛋白样沉积、白色或红色胎盘梗死、绒毛间隙血栓形成、边缘或基底蜕膜血肿、钙质沉积、脐带血栓形成，另一方面揭示了微观发现：胎盘梗死、纤维蛋白样坏死、子宫肌层血栓形成、子宫肌层退行性病变、局灶性子宫肌层坏死、绒毛淤滞和坏死、脐带血栓形成。由于APS中血栓形成倾向增加，任何血管或器官都可能受累，GBTS的组成部分也不例外。产科APS妊娠并发症的基础是胎儿附属器和子宫结构中发生形态病理学变化。
