Yan Hainian, Koyano Shin, Inami Yuhki, Yamamoto Yumiko, Suzutani Tatsuo, Mizuguchi Masashi, Ushijima Hiroshi, Kurane Ichiro, Inoue Naoki
Department of Virology I, National Institute of Infectious Diseases, 1-23-1 Toyama, Shinjuku-ku, Tokyo, 162-8640, Japan.
Arch Virol. 2008;153(4):667-74. doi: 10.1007/s00705-008-0044-7. Epub 2008 Feb 14.
Human cytomegalovirus (CMV) is the leading cause of intrauterine viral infection. The association of genetic polymorphisms in some particular genes with the incidence and severity of congenital infection has been controversial. To address this issue, we analyzed the genotypes of the glycoprotein B (gB), UL144 and UL149 genes of CMV clinical strains obtained from 33 congenitally and 31 postnatally infected Japanese children. Our results demonstrated that (1) CMV strains with any combination of genotypes could be vertically transmitted from mother to fetus, potentially causing neurological abnormalities, (2) the gB3 genotype was more prevalent in the congenital cases than in postnatally infected children (P < 0.05), particularly in congenital cases with sensorineural hearing loss (P = 0.009), (3) there was no relationship between gB genotype and viral load in the urine and dried umbilical cord specimens in the congenital cases, and (4) the UL144 and UL149 genotype distributions had no bias for congenial infection. In future studies, it would be interesting to see whether the gB genotypes serve as a prognostic indicator of CMV-associated diseases.
人巨细胞病毒（CMV）是宫内病毒感染的主要原因。某些特定基因中的遗传多态性与先天性感染的发生率和严重程度之间的关联一直存在争议。为了解决这个问题，我们分析了从33名先天性感染和31名出生后感染的日本儿童中获得的CMV临床菌株的糖蛋白B（gB）、UL144和UL149基因的基因型。我们的结果表明：（1）任何基因型组合的CMV菌株都可能从母亲垂直传播给胎儿，潜在地导致神经异常；（2）gB3基因型在先天性病例中比在出生后感染的儿童中更普遍（P < 0.05），特别是在伴有感音神经性听力损失的先天性病例中（P = 0.009）；（3）在先天性病例中，gB基因型与尿液和干燥脐带标本中的病毒载量之间没有关系；（4）UL144和UL149基因型分布在先天性感染方面没有偏差。在未来的研究中，观察gB基因型是否可作为CMV相关疾病的预后指标将是很有趣的。
