巨细胞病毒的遗传多样性与进化：对基因型及其在病毒致病机制中作用的见解

Cytomegalovirus Genetic Diversity and Evolution: Insights into Genotypes and Their Role in Viral Pathogenesis.

作者信息

Venturini Cristina, Breuer Judith

机构信息

Department of Infection, Immunity and Inflammation, Great Ormond Street Institute of Child Health, University College London, London WC1N 1EH, UK.

出版信息

Pathogens. 2025 Jan 9;14(1):50. doi: 10.3390/pathogens14010050.

DOI:10.3390/pathogens14010050

PMID:39861011

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11768282/

Abstract

Cytomegalovirus (CMV) is a ubiquitous virus that infects most of the human population and causes significant morbidity and mortality, particularly among immunocompromised individuals. Understanding CMV's genetic diversity and evolutionary dynamics is crucial for elucidating its pathogenesis and developing effective therapeutic interventions. This review provides a comprehensive examination of CMV's genetic diversity and evolution, focussing on the role of different genotypes in viral pathogenesis.

摘要

巨细胞病毒（CMV）是一种普遍存在的病毒，它感染了大多数人类，并导致严重的发病和死亡，尤其是在免疫功能低下的个体中。了解CMV的遗传多样性和进化动态对于阐明其发病机制和开发有效的治疗干预措施至关重要。本综述全面考察了CMV的遗传多样性和进化，重点关注不同基因型在病毒发病机制中的作用。