溃疡性结肠炎患者疾病范围和严重程度的种族差异：一项回顾性队列研究。
Racial differences in disease extent and severity in patients with ulcerative colitis: a retrospective cohort study.
作者信息
Flasar Mark H, Quezada Sandra, Bijpuria Priti, Cross Raymond K
机构信息
Veterans Affairs, Maryland Health Care System, Baltimore, MD, USA.
出版信息
Dig Dis Sci. 2008 Oct;53(10):2754-60. doi: 10.1007/s10620-007-0190-x. Epub 2008 Feb 14.
INTRODUCTION
Ulcerative colitis (UC) is increasing in African-Americans (AA). The objectives of this study were to assess disease extent and severity in UC by race.
METHODS
Disease extent and severity was assessed in UC outpatients evaluated at the University of Maryland and Baltimore VA from 1997 to 2005.
RESULTS
About 197 patients were identified; 47 were AA (23%). Of AA, 23% had proctitis, 23% had left-sided colitis, and 53% had extensive colitis compared to 10%, 31%, and 59% of Caucasians, respectively (P = 0.056). African-Americans were less likely to ever receive steroids (45% versus 62%; P = 0.065), be treated with > or = 2 courses of steroids (54% versus 68%; P = 0.242) or be steroid dependant (33% versus 46%; P = 0.304). After adjustment, only female gender (OR 0.32, [0.16-0.66]) and age at diagnosis (OR 2.50, [1.28-4.90]) were associated with extensive colitis. Being seen at UMMS (OR 5.10, [2.60-10.10]) was associated with steroid use.
CONCLUSION
Race was not associated with extent of colitis or disease severity in UC.
引言
溃疡性结肠炎（UC）在非裔美国人（AA）中的发病率正在上升。本研究的目的是按种族评估UC的疾病范围和严重程度。
方法
对1997年至2005年在马里兰大学和巴尔的摩退伍军人事务部接受评估的UC门诊患者的疾病范围和严重程度进行评估。
结果
共识别出约197例患者；其中47例为非裔美国人（23%）。在非裔美国人中，23%患有直肠炎，23%患有左侧结肠炎，53%患有广泛性结肠炎，而白种人相应的比例分别为10%、31%和59%（P = 0.056）。非裔美国人接受类固醇治疗的可能性较小（45%对62%；P = 0.065），接受≥2个疗程类固醇治疗的可能性较小（54%对68%；P = 0.242），或依赖类固醇治疗的可能性较小（33%对46%；P = 0.304）。调整后，只有女性（比值比0.32，[0.16 - 0.66]）和诊断时的年龄（比值比2.50，[1.28 - 4.90]）与广泛性结肠炎相关。在马里兰大学医学中心就诊（比值比5.10，[2.60 - 10.10]）与使用类固醇相关。
结论
种族与UC的结肠炎范围或疾病严重程度无关。
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