Chiellini Federica, Piras Anna Maria, Gazzarri Matteo, Bartoli Cristina, Ferri Marcella, Paolini Laura, Chiellini Emo
Laboratory of Bioactive Polymeric Materials for Biomedical and Environmental Applications, Department of Chemistry & Industrial Chemistry, University of Pisa, Via Vecchia Livornese 1291, 56122 San Piero a Grado, Pisa, Italy.
Macromol Biosci. 2008 Jun 11;8(6):516-25. doi: 10.1002/mabi.200700228.
Bioerodible polymers displaying both stealth and targeting properties for the preparation of nanosystems for targeted and controlled delivery of fibrinolytic drugs to the thrombus were prepared by straightforward synthetic routes and characterized. Poly[(maleic anhydride)-alt-(butylvinyl ether)]s were synthesized in the presence of dodecyl mercaptan as chain transfer agent allowing for the preparation of copolymers with tunable molecular weight. 2-Methoxyethanol hemiesters containing antiopsonizing molecules of poly(ethylene glycol) were prepared and further biofunctionalized with a Fab fragment by a two-step reaction. In vitro biocompatibility investigation of the prepared materials supported their suitability for biomedical applications.
通过直接的合成路线制备并表征了具有隐形和靶向特性的生物可蚀聚合物，用于制备纳米系统，以将纤溶药物靶向和可控地递送至血栓。在十二烷基硫醇作为链转移剂的存在下合成聚[（马来酸酐）-alt-（丁基乙烯基醚）]，从而制备出具有可调分子量的共聚物。制备了含有聚乙二醇抗调理素分子的2-甲氧基乙醇半酯，并通过两步反应进一步用Fab片段进行生物功能化。对所制备材料的体外生物相容性研究支持了它们在生物医学应用中的适用性。
