Gunella G, Zanasi A, Massimo Vanasia C B
Servizio di Fisiopatologia Respiratoria e Terapia Medica dell'Insufficienza Respiratoria, Ospedale S. Orsola, Bologna.
Clin Ter. 1991 Feb 28;136(4):261-6.
Efficacy and tolerability of an antitussive drug, levodropropizine, in 21 adult patients with interstitial lung disorders was evaluated in this study. Levodropropizine dosage was 60 mg t.i.d. for four days of therapy. The authors evaluated the effectiveness of the antitussive therapy and, on the other hand, the tolerability of levodropropizine in these patients, monitoring PaO2, PaCO2 and pH values. The changes in cough frequency (34.1 +/- 5.6 20.4 +/- 5.4 mean +/- d.s. before and after treatment) and the overall efficacy judgment as reported by the doctor indicate a decrease in cough as confirmed by the significance of Kruskal-Wallis test (p less than 0.05). Furthermore the tolerability has been excellent, because the PaO2, PaCo2 ad pH values before and after treatment were unchanged (PaO2 mmHg: basal 71 +/- 16.6, after treatment 73.8 +/- 14.2; PaCO2 mmHg: basal 36.6 +/- 5, after treatment 36.6 +/- 4.6; pH basal 7.4 +/- 0.03, after treatment 7.4 +/- 0.02).
本研究评估了镇咳药左羟丙哌嗪在21例成年间质性肺疾病患者中的疗效和耐受性。左羟丙哌嗪剂量为60毫克，每日三次，治疗四天。作者评估了镇咳治疗的有效性，另一方面，评估了左羟丙哌嗪在这些患者中的耐受性，监测动脉血氧分压（PaO2）、动脉血二氧化碳分压（PaCO2）和pH值。咳嗽频率的变化（治疗前后分别为34.1±5.6、20.4±5.4，均值±标准差）以及医生报告的总体疗效判断表明咳嗽有所减轻，经克鲁斯卡尔-沃利斯检验具有显著性（p<0.05）。此外，耐受性良好，因为治疗前后的PaO2、PaCO2和pH值未发生变化（PaO2，毫米汞柱：基础值71±16.6，治疗后73.8±14.2；PaCO2，毫米汞柱：基础值36.6±5，治疗后36.6±4.6；pH基础值7.4±0.03，治疗后7.4±0.02）。
