Bejor M, Arrigo A
Centro di Neurofisiologia Clinica, Università degli Studi di Pavia.
Clin Ter. 1990 Jun 30;133(6):393-9.
This study proves that L-dropropizine, a new peripheral antitussive drug, does not hinder the positive and useful effect of cough. This is particularly the case of physiokinesis in chronic obstructive lung disease patients. To quantify results, the respiratory voluntary muscles have been examined by surface electromyography and the peak expiratory flow has been registered by a computer-assisted device. By analysing the curves obtained relating the intensity of muscle contraction to expiratory flow, i.e. the muscle work exerted, no difference has been found after L-dropropizine and placebo. Statistical analysis evidenced increase in maximal peak expiratory flow and decrease in muscle work with both therapies. Both were significant (Student's test for paired data: p less than 0.01) in attaining functional improvement. Levodropropizine does not seem to impair the efficacy of cough elicited as part of respiratory clearance mechanisms.
本研究证明，新型外周性镇咳药左羟丙哌嗪不会妨碍咳嗽的积极有益作用。慢性阻塞性肺疾病患者的身体活动尤其如此。为了量化结果，通过表面肌电图检查呼吸随意肌，并使用计算机辅助设备记录呼气峰值流速。通过分析所获得的将肌肉收缩强度与呼气流量相关联的曲线，即所施加的肌肉功，发现左羟丙哌嗪和安慰剂给药后没有差异。统计分析表明，两种治疗方法均使最大呼气峰值流速增加，肌肉功降低。在实现功能改善方面，两者均具有显著性（配对数据的学生检验：p<0.01）。左羟丙哌嗪似乎不会损害作为呼吸清除机制一部分而引发的咳嗽的功效。
