Ravindra Kadiyala V, Eng Mary, Marvin Michael
Division of Transplantation, Department of Surgery, University of Louisville, Louisville, KY 40292, USA.
Am Surg. 2008 Jan;74(1):4-10.
Portal hypertension resulting from cirrhosis was one of the biggest challenges faced by general surgeons up until the past two decades. The management of portal hypertensive variceal hemorrhage has undergone dramatic changes during this period. Endoscopic variceal ligation and transjugular intrahepatic portosystemic shunts are currently used with great success. The degree of liver dysfunction remains the most important determinant of outcome in these patients. Patients with cirrhosis who have good liver function and recurrent variceal bleed remain candidates for shunt surgery. However, the need for surgical intervention has become a rarity. The success of liver transplantation has ensured that portal hypertension is cured permanently and one does not often see the critically ill and decompensated patient with cirrhosis on the surgical service. A review of the current treatment options in this very ill patient population is the primary focus of this article.
直到过去二十年,肝硬化所致门静脉高压一直是普通外科医生面临的最大挑战之一。在此期间,门静脉高压性静脉曲张出血的治疗发生了巨大变化。目前,内镜下静脉曲张结扎术和经颈静脉肝内门体分流术取得了巨大成功。肝功能障碍的程度仍然是这些患者预后的最重要决定因素。肝功能良好且静脉曲张反复出血的肝硬化患者仍是分流手术的候选者。然而,手术干预的需求已变得罕见。肝移植的成功确保了门静脉高压得到永久性治愈,外科病房里也不常见到病情危重、失代偿的肝硬化患者。本文的主要重点是对这类重症患者群体当前治疗选择的综述。