Vestergaard P, Aagaard J
Clinical Department A, Psychiatric Hospital, Risskov, Denmark.
J Affect Disord. 1991 Jan;21(1):33-8. doi: 10.1016/0165-0327(91)90016-l.
A hundred and thirty-three affective disorder patients who received prophylactic treatment with lithium were followed prospectively for 5 years and their mortality was recorded. Twenty-two patients died during the period, 13 from natural causes and nine from definite or probable suicide. The observed mortality was significantly greater than the expected overall, and also when natural causes and suicide were considered independently. No patients died from lithium intoxication or lithium-induced side effects. Patients who died from suicide were all bipolars or suffered from affective disorder with uncertain polarity. They were significantly younger than the patients who died from natural causes, they tended to lead isolated lives and they suffered a violent death. The older patients who died from natural causes had often had physical illness and alcohol abuse prior to the start of lithium treatment. The results of the study speak in favour of the establishment of comprehensive treatment programmes possibly in the framework of specialised affective disorder clinics.
对133例接受锂盐预防性治疗的情感障碍患者进行了为期5年的前瞻性随访，并记录了他们的死亡率。在此期间有22例患者死亡，13例死于自然原因，9例死于明确或可能的自杀。观察到的死亡率总体上显著高于预期，分别考虑自然原因和自杀时也是如此。没有患者死于锂中毒或锂引起的副作用。死于自杀的患者均为双相情感障碍患者或极性不确定的情感障碍患者。他们比死于自然原因的患者明显年轻，往往过着孤独的生活，且死于暴力。死于自然原因的老年患者在开始锂治疗前常有身体疾病和酗酒史。该研究结果支持可能在专门的情感障碍诊所框架内建立综合治疗方案。
