Nyberg Anders, Skagius Elisabet, Nilsson Ingrid, Ljungh Asa, Henriksson Anders E
Department of Clinical Bacteriology, Sundsvall County Hospital, Sundsvall, Sweden.
Scand J Infect Dis. 2008;40(3):204-7. doi: 10.1080/00365540701642153.
The aim of the present study was to investigate whether virulent CagA positive Helicobacter pylori strains are those preferentially related to abdominal aortic aneurysm (AAA) rupture. Several microorganisms have been linked to aneurysm development. Chronic Chlamydophila pneumoniae infection has been suggested as a possible contributing factor for the development and expansion of AAA. Previous studies have shown increased risk of carotid atherosclerosis and coronary heart disease in subjects harbouring CagA positive strains of H. pylori. The relevance of CagA positive H. pylori involved in the processes underlying aneurysmal development, expansion, and rupture is unknown. In a case-control study, 119 patients with AAA and 36 matched controls were prospectively investigated with H. pylori serology. Patients with ruptured AAA have similar levels of IgG antibodies against H. pylori to patients with electively operated AAA, small AAA, and controls. In conclusion, this study fails to demonstrate a connection between H. pylori CagA seropositivity and abdominal aortic aneurysm rupture.
本研究的目的是调查具有毒力的细胞毒素相关基因A（CagA）阳性幽门螺杆菌菌株是否优先与腹主动脉瘤（AAA）破裂相关。几种微生物已被证明与动脉瘤的发展有关。慢性肺炎衣原体感染被认为是腹主动脉瘤发生和扩张的一个可能促成因素。先前的研究表明，携带CagA阳性幽门螺杆菌菌株的受试者患颈动脉粥样硬化和冠心病的风险增加。CagA阳性幽门螺杆菌在动脉瘤发生、扩张和破裂过程中的相关性尚不清楚。在一项病例对照研究中，对119例腹主动脉瘤患者和36例匹配的对照进行了幽门螺杆菌血清学的前瞻性调查。AAA破裂患者与择期手术的AAA患者、小AAA患者及对照相比，其抗幽门螺杆菌IgG抗体水平相似。总之，本研究未能证明幽门螺杆菌CagA血清阳性与腹主动脉瘤破裂之间存在关联。
