Somi Mohammad H, Fattahi Ebrahim, Fouladi Rohollah F, Karimi Mohsen, Bonyadi Reza, Baballou Zohreh
Liver & Gastroenterology Diseases Research Center, Tabriz Medical Sciences University, Tabriz, Iran.
Saudi Med J. 2008 Mar;29(3):393-6.
The aim of this study is investigating the association of Helicobacter pylori (H. pylori) infection and its cytotoxic-associated gene A (cagA) strain with reflux esophagitis.
In a case-control setting (May 2005-2006), patients with reflux esophagitis (case group) were compared with age and gender matched people suffering from symptoms of gastroesophageal reflux disease with normal upper gastrointestinal endoscopic findings (control group) in Imam Khomeini Hospital, Tabriz, Iran. The rates of H. pylori and its cagA positive infections were separately compared between the 2 groups and the subgroups with different severity of reflux esophagitis.
Ninety-two and 93 patients were enrolled in the case and the control groups. The rate of H. pylori infection was insignificantly lower in the case group (81.5% versus 87.10%, p=0.29, odd ratio 0.654, 95% Confidence interval [CI] 0.293 to 1.495). The CagA positive infections were found significantly more frequent in the control group (59.1% versus 40.2%, p=0.01, odd ratio 0.465, 95% CI 0.258 to 0.836). There was no significant difference between the severity subgroups of the disease for H. pylori (p=0.30) or cagA positive infection rates (p=0.40).
The CagA positive strains might have a protective effect against reflux esophagitis.
本研究旨在调查幽门螺杆菌（H. pylori）感染及其细胞毒素相关基因A（cagA）菌株与反流性食管炎之间的关联。
在病例对照研究中（2005年5月至2006年），将伊朗大不里士伊玛目霍梅尼医院的反流性食管炎患者（病例组）与年龄和性别相匹配、有胃食管反流病症状但上消化道内镜检查结果正常的人（对照组）进行比较。分别比较两组以及反流性食管炎不同严重程度亚组中幽门螺杆菌及其cagA阳性感染的发生率。
病例组和对照组分别纳入92例和93例患者。病例组幽门螺杆菌感染率略低，但无统计学意义（81.5%对87.10%，p = 0.29，比值比0.654，95%置信区间[CI] 0.293至1.495）。对照组中cagA阳性感染明显更常见（59.1%对40.2%，p = 0.01，比值比0.465，95% CI 0.258至0.836）。疾病严重程度亚组之间幽门螺杆菌感染率（p = 0.30）或cagA阳性感染率（p = 0.40）无显著差异。
cagA阳性菌株可能对反流性食管炎有保护作用。
