Ramazzotti Anna, Pepe Alessia, Positano Vincenzo, Scattini Barbara, Santarelli Maria F, Landini Luigi, De Marchi Daniele, Keilberg Petra, Derchi Giorgio, Formisano Francesco, Pili Marcello, Lai Maria E, Forni Gianluca, Filosa Aldo, Prossomariti Luciano, Capra Marcello, Pitrolo Lorella, Borgna-Pignatti Caterina, Cianciulli Paolo, Maggio Aurelio, Lombardi Massimo
Magnetic Resonance Imaging Laboratory, Institute of Clinical Physiology, CNR, Pisa, Italy.
Hemoglobin. 2008;32(1-2):97-107. doi: 10.1080/03630260701879514.
Studies of the standardized, 3D, 16-segments map of the circumferential distribution of T2* values, of cardiovascular magnetic resonance (CMR) in thalassemia major (TM) and thalassemia intermedia (TI) patients and of electrocardiogram (ECG) changes associated with TM, have been carried out. Similarly, the segment-dependent correction map of the T2* values and the artifactual variations in normal subjects and the T2* correction map to correct segmental measurements in patients with different levels of myocardial iron burden have been evaluated. Cardiovascular magnetic resonance can be a suitable guide to cardiac management in TI, as well as in TM; TI patients show lower myocardial iron burden and more pronounced high cardiac output findings than TM patients. Moreover, it is proposed that, due to its good positive predictive value (PPV) and low cost, ECG can be a suitable guide to orient towards CMR examination in TM cases.
已经开展了对重型地中海贫血（TM）和中间型地中海贫血（TI）患者心血管磁共振成像（CMR）的标准化三维16节段T2值圆周分布图谱以及与TM相关的心电图（ECG）变化的研究。同样，也评估了正常受试者T2值的节段依赖性校正图谱和伪影变化，以及用于校正不同心肌铁负荷水平患者节段测量值的T2*校正图谱。心血管磁共振成像可以作为TI以及TM心脏管理的合适指导；TI患者比TM患者表现出更低的心肌铁负荷和更明显的高心输出量表现。此外，有人提出，由于心电图具有良好的阳性预测值（PPV）且成本低，因此在TM病例中，心电图可以作为引导进行CMR检查的合适指导。
