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[主动脉肺动脉瘘:HIV 感染者及静脉药物滥用患者的左侧感染性心内膜炎。文献综述]

[Aorto pulmonary fistula: left-sided infective endocarditis in HIV and intravenous drugs abuser patient. Review of the literature].

作者信息

Obón Azuara B, Zalba Etayo B, Gutiérrez Cía I, Villanueva Anadón B

机构信息

Servicio de Medicina Intensiva, Hospital Clínico Universitario, Zaragoza.

出版信息

An Med Interna. 2007 Nov;24(11):547-50. doi: 10.4321/s0212-71992007001100008.

Abstract

Infective endocarditis (IE) is the most severe complication in intravenous drug abusers (IVDAs). HIV infection increases the risk of IE in IVDAs too. IE in both population are special tendency to infect the right-sided heart, but unusual infective aortic valve. We report a case of HIV and IVDA patient admitted in hospital due to fever syndrome, with X-ray test normal and the first blood cultures negatives. CD4 count cell 90 mm3. It was impossible doing a transesophageal echocardiography (TEE) and transtoracic echocardiogramma (TTE) only showed a moderate aortic insufficiency with conserved systolic function. Despite using antibiotics, antifungals and highly active antiretroviral therapy, he developed ARDS, and mechanical ventilation should be performed. At that moment, TEE showed an aorto pulmonary fistula due to left-sided IE. Further cultures was undergone and only one blood culture was positive to Staphylococcus aureus. Cardiac surgery was not indicated. The patient died 3 weeks later.

摘要

感染性心内膜炎(IE)是静脉药物滥用者(IVDA)最严重的并发症。HIV感染也增加了IVDA患IE的风险。这两类人群中的IE都有感染右侧心脏的特殊倾向,但感染主动脉瓣的情况不常见。我们报告一例HIV合并IVDA患者,因发热综合征入院,X线检查正常,首次血培养阴性。CD4细胞计数为90/mm³。无法进行经食管超声心动图(TEE)检查,经胸超声心动图(TTE)仅显示中度主动脉瓣关闭不全,收缩功能正常。尽管使用了抗生素、抗真菌药和高效抗逆转录病毒治疗,他仍发展为急性呼吸窘迫综合征(ARDS),需要进行机械通气。此时,TEE显示因左侧IE导致的主动脉-肺动脉瘘。进一步进行培养,只有一次血培养对金黄色葡萄球菌呈阳性。未行心脏手术。患者3周后死亡。

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