Ogita Hisakazu, Takai Yoshimi
Department of Molecular Biology and Biochemistry, Osaka University Graduate School of Medicine/Faculty of Medicine, Suita, Osaka 565-0871, Japan.
Int Rev Cytol. 2008;265:1-54. doi: 10.1016/S0074-7696(07)65001-3.
Integrin, cadherin, and growth factor receptor are key molecules for fundamental cellular functions including cell movement, proliferation, differentiation, adhesion, and survival. These cell surface molecules cross-talk with each other in the regulation of such cellular functions. Nectin and nectin-like molecule (Necl) have been identified as cell adhesion molecules that belong to the immunoglobulin superfamily. Nectin and Necl play important roles in the integration of integrin, cadherin, and growth factor receptor at the cell-cell adhesion sites of contacting cells and at the leading edges of moving cells, and thus are also involved in the fundamental cellular functions together with integrin, cadherin, and growth factor receptor. This chapter describes how newly identified cell adhesion molecules, nectin and Necl, modulate the cross-talk among integrin, cadherin, and growth factor receptor and how these integrated molecules act in the regulation of fundamental cellular functions.
整合素、钙黏着蛋白和生长因子受体是细胞基本功能的关键分子，这些功能包括细胞运动、增殖、分化、黏附及存活。这些细胞表面分子在调节此类细胞功能时相互作用。Nectin和Nectin样分子（Necl）已被鉴定为属于免疫球蛋白超家族的细胞黏附分子。Nectin和Necl在接触细胞的细胞间黏附位点以及移动细胞的前沿，于整合素、钙黏着蛋白和生长因子受体的整合过程中发挥重要作用，因此也与整合素、钙黏着蛋白和生长因子受体共同参与细胞的基本功能。本章描述了新发现的细胞黏附分子Nectin和Necl如何调节整合素、钙黏着蛋白和生长因子受体之间的相互作用，以及这些整合分子如何在细胞基本功能的调节中发挥作用。
