Kobecki Jakub, Gajdzis Paweł, Mazur Grzegorz, Chabowski Mariusz
Department of Surgery, 4th Military Teaching Hospital, 5 Weigla Street, 50-981 Wroclaw, Poland.
Division of Anaesthesiological and Surgical Nursing, Department of Nursing and Obstetrics, Faculty of Health Science, Wroclaw Medical University, 5 Bartla Street, 51-618 Wroclaw, Poland.
Diagnostics (Basel). 2022 Dec 7;12(12):3076. doi: 10.3390/diagnostics12123076.
In 2020, colorectal cancer was the third most common type of cancer worldwide with a clearly visible increase in the number of cases each year. With relatively high mortality rates and an uncertain prognosis, colorectal cancer is a serious health problem. There is an urgent need to investigate its specific mechanism of carcinogenesis and progression in order to develop new strategies of action against this cancer. Nectins and Nectin-like molecules are cell adhesion molecules that take part in a plethora of essential processes in healthy tissues as well as mediating substantial actions for tumor initiation and evolution. Our understanding of their role and a viable application of this in anti-cancer therapy has rapidly improved in recent years. This review summarizes the current data on the role nectins and Nectin-like molecules play in colorectal cancer.
2020年，结直肠癌是全球第三大常见癌症类型，每年的病例数呈明显上升趋势。由于死亡率相对较高且预后不确定，结直肠癌是一个严重的健康问题。迫切需要研究其致癌和进展的具体机制，以便制定针对这种癌症的新治疗策略。NECTIN蛋白和类NECTIN分子是细胞粘附分子，它们在健康组织中参与大量重要过程，同时也介导肿瘤发生和发展的重要作用。近年来，我们对它们的作用及其在抗癌治疗中的可行应用的理解有了迅速提高。这篇综述总结了关于NECTIN蛋白和类NECTIN分子在结直肠癌中作用的现有数据。
