Li Yan, Lee In-Seop, Cui Fu-Zhai, Choi Seong-Ho
Advanced Materials Laboratory, Department of Materials Science and Engineering, Tsinghua University, Beijing 100084, China.
Biomaterials. 2008 May;29(13):2025-32. doi: 10.1016/j.biomaterials.2008.01.009. Epub 2008 Feb 13.
To achieve improved osseointegration, there have been many efforts to modify the surface composition and topography of dental implants. Recently, the anodic oxidation treatment of titanium (Ti) has attracted a great deal of attention. Meanwhile, calcium phosphate is commonly applied to metallic implants as a coating material for fast fixation and firm implant-bone attachment on the account of its demonstrated bioactive and osteoconductive properties. In the present study, anodized surface and calcium phosphate deposition by electron beam evaporation were combined. Nanostructured calcium phosphate film was deposited on the micro-arc oxidized Ti. New apatite layer formed easily on the coated film when incubating in DPBS solution at 37 degrees C. By adding basic fibroblast growth factor (bFGF) in the DPBS solution, the bFGF could be immobilized in the newly formed apatite layer. The coated film enhanced osseointegration of Ti implants in vivo.
为了实现更好的骨结合，人们在改变牙种植体的表面成分和形貌方面做出了许多努力。最近，钛（Ti）的阳极氧化处理引起了广泛关注。同时，由于磷酸钙具有已证实的生物活性和骨传导特性，它通常被用作金属植入物的涂层材料，以实现快速固定和牢固的种植体-骨附着。在本研究中，将阳极氧化表面与通过电子束蒸发进行的磷酸钙沉积相结合。纳米结构的磷酸钙膜沉积在微弧氧化的钛上。当在37℃的DPBS溶液中孵育时，新的磷灰石层很容易在涂层膜上形成。通过在DPBS溶液中添加碱性成纤维细胞生长因子（bFGF），bFGF可以固定在新形成的磷灰石层中。该涂层膜增强了钛植入物在体内的骨结合。
