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精神分裂症中的DNA与经典遗传标记

DNA and classical genetic markers in schizophrenia.

作者信息

Owen M J, McGuffin P

机构信息

Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.

出版信息

Eur Arch Psychiatry Clin Neurosci. 1991;240(3):197-203. doi: 10.1007/BF02190764.

DOI:10.1007/BF02190764
PMID:1827608
Abstract

Interest in genetic marker studies of schizophrenia has been considerably enhanced by the advent of recombinant DNA technology, which has dramatically increased the number of available markers. In the present paper, we review studies that have been carried out using classical markers as well as the more recent molecular studies. The problems that arise when schizophrenia is studied in this way are discussed and attempts are made to account for some of the conflicting findings in this area.

摘要

重组DNA技术的出现极大地增加了可用标记的数量，这使得对精神分裂症基因标记研究的兴趣大幅提升。在本文中，我们回顾了使用经典标记以及近期分子研究开展的各项研究。我们讨论了以这种方式研究精神分裂症时出现的问题，并尝试对该领域一些相互矛盾的研究结果作出解释。

相似文献

1
DNA and classical genetic markers in schizophrenia.精神分裂症中的DNA与经典遗传标记
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2
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DNA markers and biological vulnerability markers in families multiply affected with schizophrenia.精神分裂症多重患病家庭中的DNA标记物和生物易感性标记物。
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Will schizophrenia become a graveyard for molecular geneticists?精神分裂症会成为分子遗传学家的“坟墓”吗？
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本文引用的文献

1
On estimating the relation between blood group and disease.关于评估血型与疾病之间的关系。
Ann Hum Genet. 1955 Jun;19(4):251-3. doi: 10.1111/j.1469-1809.1955.tb01348.x.
2
Sequential tests for the detection of linkage.用于检测连锁的序贯检验。
Am J Hum Genet. 1955 Sep;7(3):277-318.
3
Study of HLA antigens among Japanese schizophrenics.日本精神分裂症患者的人类白细胞抗原研究。
Br J Psychiatry. 1981 Jun;138:498-500. doi: 10.1192/bjp.138.6.498.
4
Subtypes of schizophrenia and ABO blood types.精神分裂症的亚型与ABO血型
Neuropsychobiology. 1982;8(2):57-9. doi: 10.1159/000117878.
5
HLA antigens and subtypes of schizophrenia.人类白细胞抗原与精神分裂症的亚型
Psychiatry Res. 1981 Oct;5(2):115-22. doi: 10.1016/0165-1781(81)90041-x.
6
Immunoglobulin allotypes Gm and Km in chronic schizophrenia: no apparent association.慢性精神分裂症中的免疫球蛋白同种异型Gm和Km：无明显关联。
Psychol Med. 1983 Feb;13(1):27-30. doi: 10.1017/s0033291700050030.
7
Schizophrenic disorders and HLA-DR antigens.精神分裂症谱系障碍与人类白细胞抗原-DR抗原
Biol Psychiatry. 1984 Feb;19(2):121-9.
8
A search for association of HLA antigens with paranoid schizophrenia. A9 appears as a possible marker.对HLA抗原与偏执型精神分裂症关联性的研究。A9似乎是一个可能的标志物。
Tissue Antigens. 1983 Sep;22(3):186-93. doi: 10.1111/j.1399-0039.1983.tb01190.x.
9
A family study of HLA antigens and other genetic markers in schizophrenia.一项关于精神分裂症患者HLA抗原及其他遗传标记的家族研究。
Psychol Med. 1983 Feb;13(1):31-43. doi: 10.1017/s0033291700050042.
10
Possible linkage relationships between certain blood groups and schizophrenia or other psychoses.
Behav Genet. 1973 Jun;3(2):101-6. doi: 10.1007/BF01067650.