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精神分裂症中的DNA与经典遗传标记

DNA and classical genetic markers in schizophrenia.

作者信息

Owen M J, McGuffin P

机构信息

Department of Psychological Medicine, University of Wales College of Medicine, Heath Park, Cardiff, UK.

出版信息

Eur Arch Psychiatry Clin Neurosci. 1991;240(3):197-203. doi: 10.1007/BF02190764.

Abstract

Interest in genetic marker studies of schizophrenia has been considerably enhanced by the advent of recombinant DNA technology, which has dramatically increased the number of available markers. In the present paper, we review studies that have been carried out using classical markers as well as the more recent molecular studies. The problems that arise when schizophrenia is studied in this way are discussed and attempts are made to account for some of the conflicting findings in this area.

摘要

重组DNA技术的出现极大地增加了可用标记的数量,这使得对精神分裂症基因标记研究的兴趣大幅提升。在本文中,我们回顾了使用经典标记以及近期分子研究开展的各项研究。我们讨论了以这种方式研究精神分裂症时出现的问题,并尝试对该领域一些相互矛盾的研究结果作出解释。

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