Inobe Tomonao, Matouschek Andreas
Department of Biochemistry, Molecular Biology and Cell Biology, 2205 Tech Drive, Hogan 2-100 Northwestern University, Evanston, IL, USA.
Curr Opin Struct Biol. 2008 Feb;18(1):43-51. doi: 10.1016/j.sbi.2007.12.014. Epub 2008 Feb 13.
ATP-dependent proteases control diverse cellular processes by degrading specific regulatory proteins. Recent work has shown that protein substrates are specifically transferred to ATP-dependent proteases through different routes. These routes can function in parallel or independently. In all of these targeting mechanisms, it can be useful to separate two steps: substrate binding to the protease and initiation of degradation.
ATP 依赖性蛋白酶通过降解特定的调节蛋白来控制多种细胞过程。最近的研究表明，蛋白质底物通过不同途径被特异性地转移到 ATP 依赖性蛋白酶上。这些途径可以并行或独立发挥作用。在所有这些靶向机制中，将两个步骤分开可能会有所帮助：底物与蛋白酶的结合以及降解的起始。
