22-羟基尖叶番荔枝碱类似物的合成与生物活性评价
Synthesis and bioevaluation of 22-hydroxyacuminatine analogs.
作者信息
Grillet François, Baumlová Barbora, Prévost Grégoire, Constant Jean-François, Chaumeron Sophie, Bigg Dennis C H, Greene Andrew E, Kanazawa Alice
机构信息
Département de Chimie Moléculaire, UMR-5250, ICMG FR-2607, CNRS-Université Joseph Fourier, BP-53, 38041 Grenoble, France.
出版信息
Bioorg Med Chem Lett. 2008 Mar 15;18(6):2143-6. doi: 10.1016/j.bmcl.2008.01.082. Epub 2008 Jan 30.
PMID:18276141
Abstract
A series of 22-hydroxyacuminatine analogs was prepared by using different Friedländer condensations. Several of the new compounds were tested for antiproliferative activity on cancer cell lines and for topoisomerase I inhibitory activity.
摘要
通过不同的Friedländer缩合反应制备了一系列22-羟基尖刺碱类似物。对几种新化合物进行了癌细胞系抗增殖活性和拓扑异构酶I抑制活性测试。
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