锂化甲苯酰胺与苯甲腈的偶联反应在酚性苯并[c]菲啶生物碱氧化特立汉宁合成中的应用
Application of coupling reaction between lithiated toluamide and benzonitrile for the synthesis of phenolic benzo[c]phenanthridine alkaloid, oxyterihanine.
作者信息
Le Thanh Nguyen, Van Hue Thi My, Lee Suh-Hee, Choi Hyun Jin, Lee Kwang Youl, Kang Bok Yun, Cho Won-Jea
机构信息
College of Pharmacy, Research Institute of Drug Development, Chonnam National University, Gwangju 500-757, Korea.
出版信息
Arch Pharm Res. 2008 Jan;31(1):6-9. doi: 10.1007/s12272-008-1112-y.
PMID:18277600
Abstract
The total synthesis of the natural phenolic benzo[c]phenanthridine alkaloid, oxyterihanine, was accomplished via substituted 3-arylisoquinoline intermediate. The key reaction was a coupling between the o-toluamide 4 and the benzonitrile 5.
摘要
天然酚性苯并[c]菲啶生物碱氧化泰汉宁的全合成是通过取代的3-芳基异喹啉中间体完成的。关键反应是邻甲苯酰胺4和苄腈5之间的偶联反应。
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