硫醚化学在细胞铜离子识别与转运中的作用
A place for thioether chemistry in cellular copper ion recognition and trafficking.
作者信息
Davis Anna V, O'Halloran Thomas V
机构信息
Department of Chemistry, Molecular Biology and Cell Biology, Northwestern University, Evanston, Illinois 60208, USA.
出版信息
Nat Chem Biol. 2008 Mar;4(3):148-51. doi: 10.1038/nchembio0308-148.
Abstract
Over the last decade, cysteine thiolate ligands have been shown to be critical to the Cu(I) (cuprous) binding chemistry of many cytosolic metallochaperone and metalloregulatory proteins involved in copper physiology. More recently, the thioether group of methionine has begun to emerge as an important Cu(I) ligand for trafficking proteins in more oxidizing cellular environments.
摘要
在过去十年中，半胱氨酸硫醇盐配体已被证明对于许多参与铜生理过程的胞质金属伴侣蛋白和金属调节蛋白的铜（I）（亚铜）结合化学至关重要。最近，甲硫氨酸的硫醚基团已开始成为在氧化性更强的细胞环境中用于转运蛋白的重要铜（I）配体。
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