Loenarz Christoph, Schofield Christopher J
Chemistry Research Laboratory and the Oxford Centre for Integrative Systems Biology, Mansfield Road, Oxford OX1 3TA, UK.
Nat Chem Biol. 2008 Mar;4(3):152-6. doi: 10.1038/nchembio0308-152.
Beyond established roles in collagen biosynthesis, hypoxic signaling and fatty acid metabolism, recent reports have now revealed roles for human 2-oxoglutarate-dependent oxygenases in histone and nucleic acid demethylation and in signaling protein hydroxylation. The emerging role of these oxygenases in enabling a multiplicity of histone modifications has some analogy with their role in enabling structural diversity in secondary metabolism.
除了在胶原蛋白生物合成、缺氧信号传导和脂肪酸代谢中已确定的作用外，最近的报道还揭示了人类2-氧代戊二酸依赖性加氧酶在组蛋白和核酸去甲基化以及信号蛋白羟基化中的作用。这些加氧酶在实现多种组蛋白修饰方面的新作用与它们在次生代谢中实现结构多样性的作用有一些相似之处。
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