将定制的钴胺素递送至甲基丙二酰辅酶A变位酶。
Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase.
作者信息
Bandarian Vahe
出版信息
Nat Chem Biol. 2008 Mar;4(3):158-9. doi: 10.1038/nchembio0308-158.
Abstract
Methylmalonyl coenzyme A mutase (MCM) catalyzes the adenosylcobalamin-dependent isomerization of methylmalonyl-CoA to succinyl-CoA. Adenosyltransferase, an enzyme that carries out the final step in biosynthesis of adenosylcobalamin, is shown to be involved in delivery of the cofactor to MCM.
摘要
甲基丙二酰辅酶A变位酶（MCM）催化依赖腺苷钴胺素的甲基丙二酰辅酶A向琥珀酰辅酶A的异构化反应。腺苷转移酶是一种在腺苷钴胺素生物合成的最后一步发挥作用的酶，已证明它参与了该辅因子向MCM的传递。
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本文引用的文献
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Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria.金属伴侣蛋白MeaB的晶体结构与诱变：对甲基丙二酸尿症病因的深入了解
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