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本文引用的文献

1
Adenosyltransferase tailors and delivers coenzyme B12.腺苷转移酶修饰并递送辅酶B12。
Nat Chem Biol. 2008 Mar;4(3):194-6. doi: 10.1038/nchembio.67. Epub 2008 Feb 10.
2
Crystal structure and mutagenesis of the metallochaperone MeaB: insight into the causes of methylmalonic aciduria.金属伴侣蛋白MeaB的晶体结构与诱变：对甲基丙二酸尿症病因的深入了解
J Biol Chem. 2007 Oct 26;282(43):31308-16. doi: 10.1074/jbc.M704850200. Epub 2007 Aug 28.
3
B12 trafficking in mammals: A for coenzyme escort service.哺乳动物中的维生素B12转运：辅酶护送服务之所需
ACS Chem Biol. 2006 Apr 25;1(3):149-59. doi: 10.1021/cb6001174.
4
Assembly and protection of the radical enzyme, methylmalonyl-CoA mutase, by its chaperone.伴侣蛋白对自由基酶甲基丙二酰辅酶A变位酶的组装与保护作用。
Biochemistry. 2006 Aug 1;45(30):9300-6. doi: 10.1021/bi0604532.
5
Mirror "base-off" conformation of coenzyme B12 in human adenosyltransferase and its downstream target, methylmalonyl-CoA mutase.人类腺苷转移酶及其下游靶点甲基丙二酰辅酶A变位酶中辅酶B12的镜像“碱基脱离”构象
J Am Chem Soc. 2005 Jan 19;127(2):526-7. doi: 10.1021/ja044365l.
6
MeaB is a component of the methylmalonyl-CoA mutase complex required for protection of the enzyme from inactivation.MeaB是甲基丙二酰辅酶A变位酶复合物的一个组成部分，该复合物是保护该酶不被灭活所必需的。
J Biol Chem. 2004 Apr 2;279(14):13652-8. doi: 10.1074/jbc.M312852200. Epub 2004 Jan 20.
7
A new mode of B12 binding and the direct participation of a potassium ion in enzyme catalysis: X-ray structure of diol dehydratase.维生素B12结合的新模式以及钾离子在酶催化中的直接参与：二醇脱水酶的X射线结构
Structure. 1999 Aug 15;7(8):997-1008. doi: 10.1016/s0969-2126(99)80126-9.
8
How a protein binds B12: A 3.0 A X-ray structure of B12-binding domains of methionine synthase.蛋白质如何结合维生素B12：甲硫氨酸合酶的维生素B12结合结构域的3.0埃X射线结构。
Science. 1994 Dec 9;266(5191):1669-74. doi: 10.1126/science.7992050.

将定制的钴胺素递送至甲基丙二酰辅酶A变位酶。

Delivery of tailor-made cobalamin to methylmalonyl-CoA mutase.

作者信息

Bandarian Vahe

出版信息

Nat Chem Biol. 2008 Mar;4(3):158-9. doi: 10.1038/nchembio0308-158.

DOI:10.1038/nchembio0308-158
PMID:18277972
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3227859/
Abstract

Methylmalonyl coenzyme A mutase (MCM) catalyzes the adenosylcobalamin-dependent isomerization of methylmalonyl-CoA to succinyl-CoA. Adenosyltransferase, an enzyme that carries out the final step in biosynthesis of adenosylcobalamin, is shown to be involved in delivery of the cofactor to MCM.

摘要

甲基丙二酰辅酶A变位酶（MCM）催化依赖腺苷钴胺素的甲基丙二酰辅酶A向琥珀酰辅酶A的异构化反应。腺苷转移酶是一种在腺苷钴胺素生物合成的最后一步发挥作用的酶，已证明它参与了该辅因子向MCM的传递。