Morita Y, Osaki Y, Doi Y
Department of Geriatrics, Cardiology and Neurology, Kochi Medical School, Nankoku, Japan.
Acta Neurol Scand. 2008 Sep;118(3):159-63. doi: 10.1111/j.1600-0404.2007.00988.x. Epub 2008 Feb 13.
We investigated transcranial magnetic stimulation (TMS) parameters in patients with parkinsonism, particularly in the early stages of the disease.
We performed TMS in 48 patients with PD, progressive supranuclear palsy (PSP) and multiple system atrophy (MSA). We measured motor threshold (MT), latency (L), motor-evoked potential amplitude and central motor conduction time (CMCT) and cortical silent period (CSP). Furthermore, we selected and compared 27 patients with a disease duration of less than 3 years.
CMCT, MT, L and CSP were different among the three groups. Post hoc analyses revealed that CMCT and CSP were the shortest in PD, and that MT was significantly lower in PD than in MSA. In patients whose disease duration was less than 3 years, CMCT and CSP were different among the three groups. Post hoc analyses showed significantly shorter CMCT in PD.
TMS can detect the pathophysiological difference among the groups in the early stages of the disease.
我们研究了帕金森综合征患者，尤其是疾病早期患者的经颅磁刺激（TMS）参数。
我们对48例帕金森病（PD）、进行性核上性麻痹（PSP）和多系统萎缩（MSA）患者进行了TMS检查。我们测量了运动阈值（MT）、潜伏期（L）、运动诱发电位幅度和中枢运动传导时间（CMCT）以及皮质静息期（CSP）。此外，我们挑选并比较了27例病程小于3年的患者。
三组之间的CMCT、MT、L和CSP存在差异。事后分析显示，PD组的CMCT和CSP最短，且PD组的MT显著低于MSA组。在病程小于3年的患者中，三组之间的CMCT和CSP也存在差异。事后分析显示，PD组的CMCT明显更短。
TMS能够在疾病早期检测出不同组之间的病理生理差异。
