Durand Philippe, Golinelli-Pimpaneau Béatrice, Mouilleron Stéphane, Badet Bernard, Badet-Denisot Marie-Ange
Institut de Chimie des Substances Naturelles-CNRS, 1 Avenue de la Terrasse, 91198 Gif-sur-Yvette, France.
Arch Biochem Biophys. 2008 Jun 15;474(2):302-17. doi: 10.1016/j.abb.2008.01.026. Epub 2008 Feb 6.
L-Glutamine:d-fructose-6-phosphate amidotransferase, also known as glucosamine-6-phosphate synthase (GlcN6P synthase), which catalyzes the first step in a pathway leading to the formation of uridine 5'-diphospho-N-acetyl-d-glucosamine (UDP-GlcNAc), is a key point in the metabolic control of the biosynthesis of amino sugar-containing macromolecules. The molecular mechanism of the reaction catalyzed by GlcN6P synthase is complex and involves amide bond cleavage followed by ammonia channeling and sugar isomerization. This article provides a comprehensive overview of the present knowledge on this multi-faceted enzyme emphasizing the progress made during the last five years.
L-谷氨酰胺：D-果糖-6-磷酸酰胺转移酶，也称为氨基葡萄糖-6-磷酸合酶（GlcN6P合酶），催化通向尿苷5'-二磷酸-N-乙酰-D-葡萄糖胺（UDP-GlcNAc）形成途径的第一步，是含氨基糖大分子生物合成代谢控制中的关键点。GlcN6P合酶催化反应的分子机制很复杂，涉及酰胺键断裂，随后是氨通道化和糖异构化。本文全面概述了关于这种多面酶的现有知识，重点介绍了过去五年取得的进展。
