High mobility group A1 protein mediates human nitric oxide synthase 2 gene expression.
作者信息
Takamiya Rina, Baron Rebecca M, Yet Shaw-Fang, Layne Matthew D, Perrella Mark A
机构信息
Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02115, USA.
出版信息
FEBS Lett. 2008 Mar 5;582(5):810-4. doi: 10.1016/j.febslet.2008.02.008. Epub 2008 Feb 13.
Abstract
Nitric oxide synthase (NOS)2, an inducible enzyme that produces NO during inflammation, is transcriptionally regulated. Our goal was to determine whether high mobility group (HMG)A1 contributes to human (h)NOS2 gene regulation. Using a small molecule inhibitor of HMGA1 binding to DNA, or a dominant-negative form of HMGA1, we blunted the induction of hNOS2 by pro-inflammatory stimuli. Binding of HMGA1 in the region -3506 to -3375 of the hNOS2 promoter, a region not previously known to be involved in hNOS2 regulation, contributed to the induction of hNOS2 promoter in conjunction with upstream enhancer regions. We demonstrate a previously unknown role for HMGA1 in the regulation of hNOS2.
摘要
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1
Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter.
FASEB J. 2007 Feb;21(2):535-42. doi: 10.1096/fj.06-6739com. Epub 2006 Dec 8.
2
PU.1 regulates cathepsin S expression in professional APCs.
J Immunol. 2006 Jan 1;176(1):275-83. doi: 10.4049/jimmunol.176.1.275.
3
Reduction of nitric oxide synthase 2 expression by distamycin A improves survival from endotoxemia.
J Immunol. 2004 Sep 15;173(6):4147-53. doi: 10.4049/jimmunol.173.6.4147.
4
STAT-1 and c-Fos interaction in nitric oxide synthase-2 gene activation.
Am J Physiol Lung Cell Mol Physiol. 2003 Jul;285(1):L137-48. doi: 10.1152/ajplung.00441.2002.
5
Molecular mechanisms of iNOS induction by IL-1 beta and IFN-gamma in rat aortic smooth muscle cells.
Am J Physiol Cell Physiol. 2002 Jan;282(1):C144-52. doi: 10.1152/ajpcell.2002.282.1.C144.
6
DNA minor-groove recognition by small molecules.
Nat Prod Rep. 2001 Jun;18(3):291-309. doi: 10.1039/a705982e.
7
Nitric oxide synthases: structure, function and inhibition.
Biochem J. 2001 Aug 1;357(Pt 3):593-615. doi: 10.1042/0264-6021:3570593.
8
Complex regulation of human inducible nitric oxide synthase gene transcription by Stat 1 and NF-kappa B.
Proc Natl Acad Sci U S A. 2001 Jul 17;98(15):8638-43. doi: 10.1073/pnas.151239498. Epub 2001 Jul 3.
9
HMGI/Y proteins: flexible regulators of transcription and chromatin structure.
Biochim Biophys Acta. 2001 May 28;1519(1-2):13-29. doi: 10.1016/s0167-4781(01)00215-9.
10
The role of high-mobility group I(Y) proteins in expression of IL-2 and T cell proliferation.
J Immunol. 2000 Mar 15;164(6):3157-68. doi: 10.4049/jimmunol.164.6.3157.
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