Savvidou Makrina D, Xiao Qingzhong, Kaihura Christine, Anderson James M, Nicolaides Kypros H
Harris Birthright Research Centre for Fetal Medicine, King's College London, London, UK.
Am J Obstet Gynecol. 2008 Apr;198(4):414.e1-5. doi: 10.1016/j.ajog.2007.10.800. Epub 2008 Feb 15.
The objective of the study was to determine the levels of circulating endothelial progenitor cells (EPCs), which are peripheral blood mononuclear cells (PBMNCs) that contribute to vascular repair in normal pregnancy.
The concentration of EPCs in maternal blood was measured in healthy nonpregnant women (group A, n = 8), normal singleton pregnancies (group B, n = 24), and normal twin pregnancies (group C, n = 21).
In group A, the mean (SD) level of EPCs was 77.0% (8.6%) adherent PBMNCs. In group B, the mean level was lower than in group A and decreased with gestation from 61.3% (14.9%) in the first trimester to 56.0% (16.2%) in the second trimester and 52.0% (8.7%) in the third trimester (P = .001). Similarly, the level of EPCs in group C was lower than in group A and decreased with gestation from 64.6% (9.6%) in the first trimester to 65.2% (12.7%) in the second trimester and 56.4% (12.6%) in the third trimester (P = .002).
Normal pregnancy is associated with a decrease in maternal circulating levels of EPCs.
本研究的目的是确定循环内皮祖细胞（EPCs）的水平，循环内皮祖细胞是有助于正常妊娠血管修复的外周血单个核细胞（PBMNCs）。
对健康未孕女性（A组，n = 8）、正常单胎妊娠（B组，n = 24）和正常双胎妊娠（C组，n = 21）的母血中EPCs浓度进行测量。
在A组中，EPCs的平均（标准差）水平为贴壁PBMNCs的77.0%（8.6%）。在B组中，平均水平低于A组，且随孕周降低，从孕早期的61.3%（14.9%）降至孕中期的56.0%（16.2%）和孕晚期的52.0%（8.7%）（P = 0.001）。同样，C组中EPCs的水平低于A组，且随孕周降低，从孕早期的64.6%（9.6%）降至孕中期的65.2%（12.7%）和孕晚期的56.4%（12.6%）（P = 0.002）。
正常妊娠与母血中循环EPCs水平降低有关。
