Lee S-T, Chu K, Jung K-H, Kim D-H, Kim E-H, Choe V N, Kim J-H, Im W-S, Kang L, Park J-E, Park H-J, Park H-K, Song E-C, Lee S K, Kim M, Roh J-K
Stroke and Stem Cell Laboratory, Department of Neurology, Seoul National University Hospital, 28, Yongon-Dong, Chongro-Gu, Seoul, 110-744, South Korea.
Neurology. 2008 Apr 22;70(17):1510-7. doi: 10.1212/01.wnl.0000294329.93565.94. Epub 2008 Mar 19.
Migraine carries an increased risk for cardiovascular and cerebrovascular diseases that cannot be explained by traditional cardiovascular risk factors. The circulating endothelial progenitor cell (EPC) number is a surrogate biologic marker of vascular function, and diminished EPC counts are associated with higher cardiovascular risk. We investigated whether abnormalities in EPC levels and functions are present in migraine patients.
Consecutive headache patients (n =166) were enrolled, including those with tension type headache (TTH; n = 74), migraine without aura (MO; n = 67), and migraine with aura (MA; n = 25). EPC colony-forming units in peripheral blood samples and migratory capacity to chemoattractants (stromal cell-derived factor 1 and vascular endothelial growth factor) and cellular senescence levels were assayed in risk factor-matched subjects (n = 6 per group).
The TTH group had more cardiovascular risk factors, more headache days, and higher Framingham risk scores than the other two groups. Mean numbers of EPC colony-forming units were 47.8 +/- 24.3 in TTH, 20.4 +/-22.2 in MO, and 8.6 +/- 10.1 in MA patients (p < 0.001 in TTH vs MO; p = 0.001 in MO vs MA). EPC colony counts of normal subjects (n = 37) were not significantly different from those with TTH. Multiple linear regression models identified only MO, MA, and the presence of migraine (MO + MA) as significant predictors of EPC levels. In addition, EPCs from migraine patients (MO and MA) showed reduced migratory capacity and increased cellular senescence compared with EPCs from TTH or normal subjects.
Circulating endothelial progenitor cell (EPC) numbers and functions are reduced in migraine patients, suggesting that EPCs can be an underlying link between migraine and cardiovascular risk.
偏头痛患者患心血管疾病和脑血管疾病的风险增加，而传统心血管危险因素无法解释这一现象。循环内皮祖细胞（EPC）数量是血管功能的替代生物学标志物，EPC计数减少与心血管风险升高相关。我们研究了偏头痛患者是否存在EPC水平和功能异常。
纳入连续的头痛患者（n = 166），包括紧张型头痛（TTH；n = 74）、无先兆偏头痛（MO；n = 67）和有先兆偏头痛（MA；n = 25）患者。在风险因素匹配的受试者（每组n = 6）中检测外周血样本中的EPC集落形成单位、对趋化因子（基质细胞衍生因子1和血管内皮生长因子）的迁移能力以及细胞衰老水平。
与其他两组相比，TTH组有更多的心血管危险因素、更多的头痛天数和更高的弗雷明汉风险评分。TTH患者的EPC集落形成单位平均数为47.8±24.3，MO患者为20.4±22.2，MA患者为8.6±10.1（TTH与MO相比，p < 0.〇〇1；MO与MA相比，p = 0.〇〇1）。正常受试者（n = 37）的EPC集落计数与TTH患者无显著差异。多元线性回归模型仅将MO、MA以及偏头痛的存在（MO + MA）确定为EPC水平的显著预测因素。此外，与TTH或正常受试者的EPC相比，偏头痛患者（MO和MA）的EPC迁移能力降低，细胞衰老增加。
偏头痛患者循环内皮祖细胞（EPC）数量和功能降低，提示EPC可能是偏头痛与心血管风险之间的潜在联系。
