Johnson Wendy, Harris Sarah E, Starr John M, Whalley Lawrence J, Deary Ian J
Department of Psychology, University of Edinburgh, 7 George Square, Edinburgh, EH8 9JZ, UK.
Neurosci Lett. 2008 Mar 21;434(1):50-5. doi: 10.1016/j.neulet.2008.01.027. Epub 2008 Jan 17.
The Pro12Ala polymorphism of peroxisome proliferator-activated receptor-gamma (PPARG; NCBI dbSNP rs1801282) has been associated with preservation of cognitive function, decreased risk of diabetes, and increased risk of obesity. We attempted to replicate these associations, testing cognitive function and lifetime cognitive change in 519 participants who took the same cognitive test at ages 11 and 79 years. Scores were also available for other cognitive tests at age 79 years, along with history of diabetes, current Body Mass Index (BMI), and other disease and demographic variables. Pro12Ala carrier status was not directly associated with diabetes history or BMI. In carriers who contracted diabetes despite carrying the protective allele, cognitive decline as measured by one test was significantly greater than in other groups. Only six individuals fell into this group; the other cognitive tests did not show this effect. This sample did not replicate the direct association of the PPARG Pro12Ala allele with diabetes status or preserved cognitive function. The data did suggest that risk of cognitive decline is greater when Pro12Ala carriers contract diabetes.
过氧化物酶体增殖物激活受体γ（PPARG；NCBI dbSNP rs1801282）的Pro12Ala多态性与认知功能的保留、糖尿病风险降低以及肥胖风险增加有关。我们试图复制这些关联，对519名在11岁和79岁时进行相同认知测试的参与者的认知功能和终生认知变化进行测试。还提供了79岁时其他认知测试的分数，以及糖尿病史、当前体重指数（BMI）以及其他疾病和人口统计学变量。Pro12Ala携带者状态与糖尿病史或BMI无直接关联。在尽管携带保护性等位基因但仍患糖尿病的携带者中，一项测试所测量的认知衰退明显大于其他组。只有6个人属于这一组；其他认知测试未显示出这种效应。该样本未复制PPARG Pro12Ala等位基因与糖尿病状态或保留的认知功能之间的直接关联。数据确实表明，当Pro12Ala携带者患糖尿病时，认知衰退的风险更大。
