Clarke Melanie C C, Chow Chee S, Chase Janet W, Gibb Susie, Hutson John M, Southwell Bridget R
Department of Surgical Research, Royal Children's Hospital, Parkville, Melbourne, Victoria 3052, Australia.
J Pediatr Surg. 2008 Feb;43(2):320-4. doi: 10.1016/j.jpedsurg.2007.10.020.
Slow transit constipation (STC) causes intractable symptoms not readily responsive to laxatives, diet, or life-style changes. Children with STC have irregular bowel motions associated with colicky abdominal pain and frequent uncontrollable soiling. This study assessed the physical and psychosocial quality of life (QOL) in children with long-standing (> or =2 years) STC vs healthy controls.
Children (aged 8-18) were recruited from gastrointestinal and surgical clinics and a Scout Jamboree. After informed consent was obtained, the questionnaire (Pediatric Quality of Life Inventory) was administered. This consists of parallel child and parent self-report scales encompassing physical functioning, emotional functioning, social functioning, and school functioning. Higher scores indicate better QOL. P value less than .05 was considered statistically significant.
In 51 children with STC (mean, 11.5 years; male/female, 2:1) and 79 controls (mean, 12.1 years; male/female, 1.9:1), Pediatric Quality of Life Inventory QOL score was significantly lower in the STC group (72.90 vs 85.99; P < .0001). In addition, parents of children with STC reported a significantly lower QOL score than their child compared with the child's own report (64.43 vs 72.90; P = .0034). Parents of controls did not (84.25 vs 85.99; P = .12).
Slow transit constipation is a debilitating condition affecting both physical and emotional functioning in children. Parental perception of QOL is significantly worse, highlighting the considerable family impact of constipation and uncontrollable soiling.
慢传输型便秘（STC）会导致顽固性症状，对泻药、饮食或生活方式的改变反应不佳。患有STC的儿童排便不规律，伴有绞痛性腹痛和频繁的无法控制的便失禁。本研究评估了患有长期（≥2年）STC的儿童与健康对照组的身体和心理社会生活质量（QOL）。
从胃肠科和外科诊所以及童子军大会招募8至18岁的儿童。在获得知情同意后，发放问卷（儿童生活质量量表）。该问卷由平行的儿童和家长自评量表组成，涵盖身体功能、情绪功能、社会功能和学校功能。分数越高表明生活质量越好。P值小于0.05被认为具有统计学意义。
51名患有STC的儿童（平均年龄11.5岁；男/女比例为2:1）和79名对照组儿童（平均年龄12.1岁；男/女比例为1.9:1），STC组的儿童生活质量量表生活质量得分显著低于对照组（72.90对85.99；P<0.0001）。此外，与孩子自己的报告相比，STC患儿的父母报告的生活质量得分显著更低（64.43对72.90；P = 0.0034）。对照组儿童的父母则没有这种情况（84.25对85.99；P = 0.12）。
慢传输型便秘是一种使人衰弱的疾病，会影响儿童的身体和情绪功能。父母对生活质量的感知明显更差，这突出了便秘和无法控制的便失禁对家庭的重大影响。
