皮肤病理学与分子遗传学。

Dermatopathology and molecular genetics.

作者信息

Bergman Reuven

机构信息

Department of Dermatology, Rambam Medical Center, Haifa, Israel.

出版信息

J Am Acad Dermatol. 2008 Mar;58(3):452-7. doi: 10.1016/j.jaad.2007.12.008.

DOI:10.1016/j.jaad.2007.12.008

PMID:18280342

Abstract

The diagnosis of inherited skin diseases has been traditionally been based on clinical findings and occasionally on dermatopathology. Recent developments in molecular genetics have increased tremendously the diagnostic accuracy of genetic skin diseases, but also expanded the role of dermatopathology in the diagnosis and understanding of the pathogenesis of inherited skin diseases. The following is a review of some of the recent discoveries and how they interact with dermatopathology.

摘要

遗传性皮肤病的诊断传统上基于临床发现，偶尔也基于皮肤病理学。分子遗传学的最新进展极大地提高了遗传性皮肤病的诊断准确性，但同时也扩大了皮肤病理学在遗传性皮肤病诊断和发病机制理解方面的作用。以下是对一些最新发现及其与皮肤病理学相互作用方式的综述。