Peters M S, Winkelmann R K
Arch Dermatol. 1980 Dec;116(12):1363-8.
Four patients with localized lipoatrophy were observed. All were female, and three were children. Lymphocytic panniculitis was observed in early biopsy specimens of all four cases, with focal histiocytic granulomas in one case. Later biopsy specimens in three patients showed that the inflammation was transient. These pathologic findings and reports of lipodystrophies associated with nephritis, hypocomplementemia, and other inflammatory or immunologic disorders offer an opportunity for histologic and immunologic study of such patients. Localized lipoatrophy may represent the end stage of panniculitis in a localized expression of connective tissue disease.
观察了4例局限性脂肪萎缩患者。所有患者均为女性，其中3例为儿童。在所有4例患者的早期活检标本中均观察到淋巴细胞性脂膜炎，1例有局灶性组织细胞肉芽肿。3例患者的后期活检标本显示炎症是短暂的。这些病理发现以及与肾炎、低补体血症和其他炎症或免疫性疾病相关的脂肪营养不良报告为对此类患者进行组织学和免疫学研究提供了机会。局限性脂肪萎缩可能代表结缔组织疾病局部表现中脂膜炎的终末期。
