Crosby P D, Rittmaster R S
Camp Hill Medical Centre, Department of Medicine, Dalhousie University, Halifax, Nova Scotia, Canada.
Fertil Steril. 1991 Jun;55(6):1076-81. doi: 10.1016/s0015-0282(16)54355-6.
To examine the clinical efficacy of low dose spironolactone in hirsute women.
Retrospective.
Outpatient endocrinology clinic.
One hundred nine consecutive women prescribed 75 to 100 mg/d spironolactone for at least 4 months in whom adequate follow-up data were available.
Hirsutism improved in 72% of the women. Women with regular menses, whether or not they used oral contraceptives (OCs), had the highest response rate to spironolactone (78%), whereas women with irregular menses who did not use an OC had the lowest response rate (55%). Favorable responses were associated with increased severity of hirsutism (P = 0.04) and lower serum dehydroepiandrosterone sulfate levels (P = 0.05). Responders and nonresponders did not differ significantly in age (P = 0.10), duration of hirsutism (P = 0.14), pretreatment serum testosterone (T) (P = 0.48), or body mass index (P = 0.11). However, when each parameter was divided into subsets, trends toward decreasing response were observed with increasing age, duration of hirsutism over 15 years, and increasing serum T level.
Low-dose spironolactone improves hirsutism in a majority of hirsute women, irrespective of age, severity or duration of hirsutism, menstrual status, or serum hormone levels.
探讨低剂量螺内酯治疗多毛女性的临床疗效。
回顾性研究。
门诊内分泌诊所。
109例连续的女性患者，她们服用75至100mg/d螺内酯至少4个月，且有足够的随访数据。
72%的女性多毛症状改善。月经规律的女性，无论是否使用口服避孕药（OCs），对螺内酯的反应率最高（78%），而月经不规律且未使用OCs的女性反应率最低（55%）。良好反应与多毛症严重程度增加（P = 0.04）和血清硫酸脱氢表雄酮水平降低（P = 0.05）相关。反应者和无反应者在年龄（P = 0.10）、多毛症持续时间（P = 0.14）、治疗前血清睾酮（T）水平（P = 0.48）或体重指数（P = 0.11）方面无显著差异。然而，当将每个参数分为子集时，随着年龄增加、多毛症持续时间超过15年以及血清T水平升高，观察到反应降低的趋势。
低剂量螺内酯可改善大多数多毛女性的多毛症状，无论其年龄、多毛症的严重程度或持续时间、月经状况或血清激素水平如何。
