Ylöstalo P, Heikkinen J, Kauppila A, Pakarinen A, Järvinen P A
Int J Fertil. 1987 Jan-Feb;32(1):41-5.
Twelve women, 11 with hirsutism and one with alopecia areata, were treated with low-dose spironolactone (50 mg daily) from the 4th until the 22nd cycle day over 12 consecutive menstrual cycles. Eight hirsute women observed a favorable effect on hirsutism in 3 to 8 months, and hair loss ceased in the one patient with alopecia areata. No significant side effects occurred. Low-dose spironolactone decreased the concentration of total and free testosterone and elevated the concentration of prolactin on the 10th cycle day, while LH, FSH, estradiol, progesterone, DHEAS, SHBG, and cortisol levels remained unchanged. The plasma aldosterone concentration increased significantly during the treatment, although serum potassium and sodium concentrations remained unchanged. Low-dose spironolactone is, thus, safe and effective in the treatment of hirsutism. It seems to be useful as an initial or alternative treatment.
12名女性，其中11名患有多毛症，1名患有斑秃，在连续12个月经周期的第4天至第22天接受低剂量螺内酯（每日50毫克）治疗。8名多毛症女性在3至8个月内观察到对多毛症有良好效果，斑秃患者的脱发停止。未出现明显副作用。低剂量螺内酯在第10个周期日降低了总睾酮和游离睾酮的浓度，并提高了催乳素的浓度，而促黄体生成素（LH）、促卵泡生成素（FSH）、雌二醇、孕酮、硫酸脱氢表雄酮（DHEAS）、性激素结合球蛋白（SHBG）和皮质醇水平保持不变。治疗期间血浆醛固酮浓度显著升高，尽管血清钾和钠浓度保持不变。因此，低剂量螺内酯治疗多毛症安全有效。它似乎可作为初始治疗或替代治疗方法。
