Elliott Michael R, Ravichandran Kodi S
Carter Immunology Center and the Department of Microbiology, University of Virginia, Charlottesville, VA 22908, USA.
Trends Cell Biol. 2008 Mar;18(3):95-7. doi: 10.1016/j.tcb.2007.12.005. Epub 2008 Feb 15.
Engulfment and prompt removal of apoptotic cells occurs from embryogenesis throughout the lifespan of multicellular organisms. A new player, Pallbearer, has recently been identified in Drosophila as being important for efficient engulfment by macrophages. Pallbearer is a component of the SCF E3 ubiquitin ligase complex involved in the ubiquitylation of proteins targeted for proteasomal degradation. This work provides the first link between the cellular processes of ubiquitylation/proteasomal degradation and the ability to clear apoptotic cells efficiently.
从胚胎发生到多细胞生物体的整个生命周期，凋亡细胞的吞噬和迅速清除都会发生。最近在果蝇中发现了一个新角色——搬运工蛋白，它对巨噬细胞的有效吞噬很重要。搬运工蛋白是SCF E3泛素连接酶复合体的一个组成部分，参与靶向蛋白酶体降解的蛋白质的泛素化过程。这项工作首次建立了泛素化/蛋白酶体降解的细胞过程与有效清除凋亡细胞能力之间的联系。
