889例细菌性脑膜炎患儿的细菌性脑膜炎评分敏感性
Sensitivity of the bacterial meningitis score in 889 children with bacterial meningitis.
作者信息
Dubos François, De la Rocque France, Levy Corinne, Bingen Edouard, Aujard Yannick, Cohen Robert, Bréart Gérard, Gendrel Dominique, Chalumeau Martin
机构信息
Clinical Epidemiology Unit, Department of Pediatrics, Saint-Vincent-de-Paul Hospital, AP-HP and Paris Descartes University, Paris, France.
出版信息
J Pediatr. 2008 Mar;152(3):378-82. doi: 10.1016/j.jpeds.2007.07.012. Epub 2007 Oct 22.
OBJECTIVE
To validate sensitivity of the bacterial meningitis score (BMS) in a large population of children with bacterial meningitis (BM).
STUDY DESIGN
Secondary analysis of prospective data for children presenting with BM to a hospital emergency department between January 2001 and February 2005. The BMS was applied to all children with acute BM using the same inclusion criteria proposed by the authors of the rule. The sensitivity of the rule was calculated.
RESULTS
Of the 900 children aged 29 days to 18 years with acute BM who met all inclusion criteria, 889 had enough data for assigning the BMS. Use of the BMS correctly identified 884 children with BM, for 99.6% sensitivity (95% confidence interval: 98.9% to 99.8%).
CONCLUSIONS
The sensitivity of the BMS to detect disease was very high, but a few cases of BM were missed. Further refinements of the BMS may be warranted to lower the false-negative rate.
目的
在大量细菌性脑膜炎（BM）患儿群体中验证细菌性脑膜炎评分（BMS）的敏感性。
研究设计
对2001年1月至2005年2月间因BM到医院急诊科就诊的患儿的前瞻性数据进行二次分析。采用该评分规则作者提出的相同纳入标准，将BMS应用于所有急性BM患儿。计算该规则的敏感性。
结果
在900例年龄在29天至18岁、符合所有纳入标准的急性BM患儿中，889例有足够数据用于评定BMS。使用BMS正确识别出884例BM患儿，敏感性为99.6%（95%置信区间：98.9%至99.8%）。
结论
BMS检测疾病的敏感性非常高，但仍有少数BM病例被漏诊。可能需要对BMS进行进一步优化以降低假阴性率。
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