Stellbrink H J, Albrecht H, Löning T, Greten H
Medizinische Kernklinik und Poliklinik, Universitätskrankenhaus Eppendorf, Hamburg.
Klin Wochenschr. 1991 Apr 4;69(6):274-8. doi: 10.1007/BF01666854.
The case of a 25-year-old homosexual man with large inguinal and perianal ulcers is reported. He had been pretreated extensively with acyclovir. Herpes simplex virus (HSV) was identified in the ulcer tissue by in-situ hybridization. No clinical improvement with acyclovir but a prompt response to foscarnet was noted. In a relapse after 11 weeks an acyclovir-resistant HSV type 2 was isolated. Again, a prompt response to foscarnet was noted. The case is presented in detail, and the clinical impact of resistance of HSV to acyclovir is discussed.
报告了一名25岁同性恋男性患有腹股沟和肛周大面积溃疡的病例。他此前已接受了广泛的阿昔洛韦预处理。通过原位杂交在溃疡组织中鉴定出单纯疱疹病毒（HSV）。使用阿昔洛韦治疗后未见临床改善，但对膦甲酸钠有迅速反应。在11周后的复发中，分离出一株对阿昔洛韦耐药的2型HSV。再次观察到对膦甲酸钠有迅速反应。详细介绍了该病例，并讨论了HSV对阿昔洛韦耐药的临床影响。
