Bob P, Chladek J, Susta M, Glaslova K, Jagla F, Kukleta M
Center for Neuropsychiatric Research of Traumatic Stress, First Faculty of Medicine, Charles University, Prague, Czech Republic.
Gen Physiol Biophys. 2007 Dec;26(4):298-305.
Recent data indicate that random-like processes are related to the defects in the organization of semantic memory in schizophrenia which is more disorganized and less definable than those of controls with more semantic links and more bizarre and atypical associations. These aspects of schizophrenic cognition are similar to characteristics of chaotic nonlinear dynamical systems. In this context, the hypothesis tested in this study is that dynamic changes of electrodermal activity (EDA) as a measure of brain and autonomic activity may serve as a characteristic which can be used as an indicator of possible neural chaotic process in schizophrenia. In the present study, bilateral EDA in rest conditions were measured in 40 schizophrenic patients and 40 healthy subjects. Results of nonlinear and statistical analysis indicate left-side significant differences of positive largest Lyapunov exponents in schizophrenia patients compared to the control group. This might be interpreted that the neural activity during rest in schizophrenic patients is significantly more chaotic than in the control group. The relationship was confirmed by surrogate data testing. These data suggest that increased neural chaos in patients with schizophrenia may influence brain processes that can cause random-like disorganization of mental processes.
近期数据表明，类似随机的过程与精神分裂症语义记忆组织缺陷有关，与对照组相比，精神分裂症患者的语义记忆组织更紊乱、更难界定，对照组的语义联系更多，关联更奇异、更不典型。精神分裂症认知的这些方面类似于混沌非线性动力系统的特征。在此背景下，本研究检验的假设是，作为大脑和自主神经活动指标的皮肤电活动（EDA）的动态变化，可能是可用于指示精神分裂症潜在神经混沌过程的一个特征。在本研究中，对40名精神分裂症患者和40名健康受试者在静息状态下的双侧EDA进行了测量。非线性和统计分析结果表明，与对照组相比，精神分裂症患者左侧的最大正李雅普诺夫指数存在显著差异。这可能意味着，精神分裂症患者静息时的神经活动比对照组明显更混沌。替代数据测试证实了这种关系。这些数据表明，精神分裂症患者神经混沌增加可能会影响大脑过程，进而导致心理过程出现类似随机的紊乱。
