长期使用血管加压素类似物进行治疗会改变大鼠大脑中隔区和杏仁核中血管加压素受体的亲和力。
Chronic treatment with vasopressin analogues alters affinity of vasopressin receptors in the septum and amygdala of the rat brain.
作者信息
Swank M W, Dorsa D M
机构信息
Geriatric Research, Education, and Clinical Center, Veterans Administration Medical Center, Seattle, WA 98108.
出版信息
Brain Res. 1991 Mar 29;544(2):342-4. doi: 10.1016/0006-8993(91)90077-9.
PMID:1828186
Abstract
Accurel devices were used to administer AVP or AVP-antagonist into the lateral ventricle of the rat brain for 7 days. Neither AVP nor antagonist altered total binding site concentration in either septum or amygdala. However, treatment with antagonist caused a marked decrease in the affinity of the receptor for agonist in both the septum and amygdala.
摘要
使用Accurel装置将血管加压素（AVP）或AVP拮抗剂注入大鼠脑侧脑室，持续7天。AVP和拮抗剂均未改变隔区或杏仁核中的总结合位点浓度。然而，拮抗剂处理导致隔区和杏仁核中受体对激动剂的亲和力显著降低。
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