Hunter Sharon K, Corral Nereida, Ponicsan Heather, Ross Randal G
Department of Psychiatry, University of Colorado at Denver and the Health Sciences Center, Denver, Colorado 80262, USA.
Neuroreport. 2008 Jan 8;19(1):79-82. doi: 10.1097/WNR.0b013e3282f35823.
This study assessed reliability of auditory sensory gating in young infants from 1-4 months of age using a paired-click paradigm in which auditory 'clicks' were presented at an interstimulus interval of 500 ms. Evoked potential component P1 was measured during periods of active sleep on two different occasions. Amplitudes, latencies, and ratio of the evoked potentials to each of the auditory clicks were compared. Significant reliability was found in the response ratio, response latency to the first stimulus, and response amplitude to the second stimulus, with a trend toward significance for response latency to the second stimulus and response amplitude to the first stimulus. The results suggest that auditory sensory gating can be reliably measured during active sleep in young infants and might be a useful tool in the study of neurodevelopmental disorders.
本研究采用配对点击范式，以500毫秒的刺激间隔呈现听觉“咔哒”声，评估了1至4个月大婴儿听觉感觉门控的可靠性。在两个不同的场合，于主动睡眠期间测量诱发电位成分P1。比较了诱发电位的幅度、潜伏期以及对每个听觉点击的反应比率。在反应比率、对第一个刺激的反应潜伏期和对第二个刺激的反应幅度方面发现了显著的可靠性，对第二个刺激的反应潜伏期和对第一个刺激的反应幅度有显著趋势。结果表明，在婴儿主动睡眠期间可以可靠地测量听觉感觉门控，这可能是研究神经发育障碍的一个有用工具。
