对咪康唑的接触性敏感与对其他咪唑类药物的邻氯交叉敏感性。
Contact sensitivity to miconazole with ortho-chloro cross-sensitivity to other imidazoles.
作者信息
Baes H
机构信息
Department of Dermatology, H. Serruys Hospital, Ostend, Belgium.
出版信息
Contact Dermatitis. 1991 Feb;24(2):89-93. doi: 10.1111/j.1600-0536.1991.tb01658.x.
Abstract
A case of allergic contact dermatitis from miconazole is reported. Patch testing with a series of azole antimycotics was positive only to miconazole, isoconazole, tioconazole and oxiconazole. Those reacting are all beta-substituted 1-phenethyl imidazoles with an ortho-chlorine substitution on the aromatic ring. For this hitherto unreported pattern of cross-sensitivity, the designation of "ortho-chloro cross-sensitivity" is proposed.
摘要
报告了1例由咪康唑引起的过敏性接触性皮炎病例。用一系列唑类抗真菌药进行斑贴试验，结果仅对咪康唑、异康唑、噻康唑和奥昔康唑呈阳性。发生反应的这些药物均为β-取代的1-苯乙基咪唑类，且在芳香环上有邻氯取代基。针对这种迄今未报告的交叉敏感性模式，建议命名为“邻氯交叉敏感性”。
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