Bercion Raymond, Njuimo Siméon P, Boudjeka Prisca Megne, Manirakiza Alexandre
Institut Pasteur de Bangui, Bangui, Central African Republic.
Trop Med Int Health. 2008 Apr;13(4):468-71. doi: 10.1111/j.1365-3156.2008.02023.x. Epub 2008 Feb 14.
We conducted a prospective study in four urban health care centres between January 2004 and November 2005 to determine the distribution and susceptibility patterns of Shigella strains causing invasive diarrhoea in Bangui, Central African Republic. Of the 155 Shigella isolated, Shigella flexneri (51%) and Shigella dysenteriae (30%) were the most common and the most resistant to usual antibiotics, including amoxicillin, sulphamethoxazole-trimethoprim and chloramphenicol. Though multi-drug resistance was common, no strains were resistant to quinolone and fluoroquinolones. We conclude that short-course treatments with ciprofloxacin can be recommended in Bangui for treatment of invasive diarrhoea.
2004年1月至2005年11月期间，我们在中非共和国班吉市的四个城市医疗中心进行了一项前瞻性研究，以确定引起侵袭性腹泻的志贺氏菌菌株的分布和药敏模式。在分离出的155株志贺氏菌中，弗氏志贺氏菌（51%）和痢疾志贺氏菌（30%）最为常见，并且对常用抗生素（包括阿莫西林、复方新诺明和氯霉素）耐药性最强。尽管多重耐药很常见，但没有菌株对喹诺酮类和氟喹诺酮类耐药。我们得出结论，在班吉市，侵袭性腹泻的治疗可推荐使用环丙沙星进行短疗程治疗。
