Jahan Y, Hossain A
Microbiology Department, Institute of Epidemiology, Disease Control and Research, Rajbari; Bangladesh.
J Diarrhoeal Dis Res. 1997 Mar;15(1):17-20.
Twenty-one Shigellae isolates were obtained from bloody faecal specimens of diarrhoeal patients at Rajbari District Hospital from January 1994 to June 1995, and serogrouped. Fourteen (67%) isolates belonged to the Shigella dysenteriae serogroup and 7 (33%) to Shigella flexneri serogroup. Shigella dysenteriae strains were further serotyped; all were Shigella dysenteriae 1. Each strain was tested for resistance to 6 common antimicrobial agents. The two strains had different antibiotic susceptibility patterns. The 7 S. flexneri showed 6 different resistant patterns and the 14 S. dysenteriae 1 isolates had 4 resistance patterns. One of the S. dysenteriae 1 isolates was resistant to all 6 antimicrobial agents; 10 to 5, and twice to a different combination of 4 antimicrobials. The 14 (100%) S. dysenteriae 1 strains were resistant to 3 major antimicrobial agents: ampicillin, tetracycline, and chloramphenicol; 13 (93%) were resistant to 5 agents: ampicillin, tetracycline, chloramphenicol, trimethoprim-sulphamethoxazole, and nalidixic acid. Ciprofloxacin was the only drug active against all 7 S. flexneri and 13 of the 14 (93%) S. dysenteriae 1 strains.
1994年1月至1995年6月期间，从拉杰巴里地区医院腹泻患者的血性粪便标本中获取了21株志贺氏菌分离株，并进行了血清分组。14株（67%）分离株属于痢疾志贺氏菌血清群，7株（33%）属于福氏志贺氏菌血清群。痢疾志贺氏菌菌株进一步进行了血清分型；均为痢疾志贺氏菌1型。对每株菌株进行了对6种常见抗菌药物的耐药性检测。这两株菌株具有不同的抗生素敏感性模式。7株福氏志贺氏菌表现出6种不同的耐药模式，14株痢疾志贺氏菌1型分离株有4种耐药模式。其中一株痢疾志贺氏菌1型分离株对所有6种抗菌药物耐药；10株对5种耐药，还有两株对4种抗菌药物的不同组合耐药。14株（100%）痢疾志贺氏菌1型菌株对3种主要抗菌药物耐药：氨苄青霉素、四环素和氯霉素；13株（93%）对5种药物耐药：氨苄青霉素、四环素、氯霉素、甲氧苄啶 - 磺胺甲恶唑和萘啶酸。环丙沙星是唯一对所有7株福氏志贺氏菌和14株（93%）痢疾志贺氏菌1型菌株中的13株有效的药物。
