Androulidakis Alexandros G, Mazzone Paolo, Litvak Vladimir, Penny Will, Dileone Michele, Gaynor Louise M F Doyle, Tisch Stephen, Di Lazzaro Vincenzo, Brown Peter
Sobell Department of Motor Neuroscience and Movement Disorders, Institute of Neurology, University College London, Queen Square, London, UK.
Exp Neurol. 2008 May;211(1):59-66. doi: 10.1016/j.expneurol.2008.01.002. Epub 2008 Jan 19.
The pedunculopontine nucleus (PPN) has recently been introduced as a new therapeutic target for deep brain stimulation (DBS) in patients suffering from Parkinson's disease (PD). In a recent case report it was demonstrated that alpha frequency oscillations appear in PPN after the administration of levodopa in PD, indicating a possible physiological role of these oscillations. Here we confirm this result and investigate the functional connectivity and reactivity of subcortical alpha activity by recording LFP activity from the PPN area and EEG in six patients with PD while at rest and in four of them while they performed ipsi- and contralateral self-paced joystick movements. Levodopa strongly promoted 7-11 Hz oscillatory synchronization in the region of PPN and coupling of this activity with similar activity in the cortical EEG. Such coupling was bidirectional. Moreover, the 7-11 Hz oscillatory synchronization in the PPN area increased about 3 s prior to self-paced movements, but only following levodopa treatment. These findings suggest that alpha oscillations in the PPN area may represent a physiological pattern of activity. The subcortical oscillations are coupled to cortical alpha activity and possibly allied to motor related attentional processes.
脚桥核（PPN）最近被提出作为帕金森病（PD）患者深部脑刺激（DBS）的一个新的治疗靶点。在最近的一篇病例报告中显示，帕金森病患者服用左旋多巴后，脚桥核会出现α频率振荡，这表明这些振荡可能具有生理作用。在此，我们证实了这一结果，并通过记录6例帕金森病患者静息时以及其中4例患者进行同侧和对侧自主节奏操纵杆运动时脚桥核区域的局部场电位（LFP）活动和脑电图（EEG），来研究皮质下α活动的功能连接性和反应性。左旋多巴强烈促进了脚桥核区域7 - 11Hz的振荡同步，并使该活动与皮质脑电图中的类似活动耦合。这种耦合是双向的。此外，脚桥核区域7 - 11Hz的振荡同步在自主节奏运动前约3秒增加，但仅在左旋多巴治疗后出现。这些发现表明，脚桥核区域的α振荡可能代表一种生理活动模式。皮质下振荡与皮质α活动耦合，并且可能与运动相关的注意力过程有关。
