Koster Annemarie, Patel Kushang V, Visser Marjolein, van Eijk Jacques Th M, Kanaya Alka M, de Rekeneire Nathalie, Newman Anne B, Tylavsky Frances A, Kritchevsky Stephen B, Harris Tamara B
Laboratory of Epidemiology, Demography, and Biometry, National Institute on Aging, Bethesda, Maryland 20892, USA.
J Am Geriatr Soc. 2008 Apr;56(4):636-43. doi: 10.1111/j.1532-5415.2007.01632.x. Epub 2008 Feb 14.
To examine joint associations of physical activity and adiposity measures (body mass index (BMI), waist circumference, percentage body fat) with incident mobility limitation.
Prospective observational cohort study.
Memphis, Tennessee and Pittsburgh, Pennsylvania.
Two thousand nine hundred and eighty-two black and white men and women aged 70 to 79 participating in the Health, Aging and Body Composition (Health ABC) study.
Mobility limitation was defined as reported difficulty walking one-quarter of a mile or climbing 10 steps during two consecutive semiannual assessments over 6.5 years. Three measures of adiposity were included in this study: BMI, total percentage body fat, and waist circumference. Physical activity was assessed using a modified leisure-time physical activity questionnaire.
Forty-six percent of the cohort developed mobility limitation. White and black men with a high BMI (> or = 30 kg/m(2)), high total percentage body fat (> 31.3%), or high waist circumference (> or = 102 cm) had an approximately 60%, 40%, and 40%, respectively, higher risk of incident mobility limitation than those with low adiposity. In women, high adiposity was also associated with a significantly higher mobility limitation risk than in those with low adiposity. Low physical activity (lowest quartile) was associated with a 70% higher risk of mobility limitation in all groups. Persons with high adiposity and low physical activity were at particularly high risk of mobility limitation. People with high adiposity who were physically active had an equally high risk of mobility limitation as inactive people with low adiposity.
High adiposity and low self-reported physical activity predicted the onset of mobility limitation in well-functioning older persons. Preventing weight gain in old age and promoting physical activity in obese and non-obese older persons may therefore be effective strategies to prevent mobility loss and future disability.
研究身体活动与肥胖指标（体重指数（BMI）、腰围、体脂百分比）与发生行动能力受限之间的联合关联。
前瞻性观察队列研究。
田纳西州孟菲斯市和宾夕法尼亚州匹兹堡市。
2982名年龄在70至79岁的黑人和白人男性及女性，参与健康、衰老与身体成分（Health ABC）研究。
行动能力受限定义为在6.5年期间连续两次半年评估中报告行走四分之一英里或爬10级台阶有困难。本研究纳入了三项肥胖指标：BMI、总体脂百分比和腰围。使用改良的闲暇时间身体活动问卷评估身体活动情况。
该队列中有46%的人出现行动能力受限。BMI高（≥30 kg/m²）、总体脂百分比高（> 31.3%）或腰围高（≥102 cm）的白人男性和黑人男性发生行动能力受限的风险分别比肥胖程度低的人高约60%、40%和40%。在女性中，肥胖程度高也与行动能力受限风险显著高于肥胖程度低的女性有关。低身体活动（最低四分位数）与所有组中行动能力受限风险高70%有关。肥胖程度高且身体活动少的人行动能力受限风险特别高。身体活跃的肥胖者与身体不活跃的低肥胖者行动能力受限风险相同。
高肥胖程度和自我报告的低身体活动预示着功能良好的老年人会出现行动能力受限。因此，预防老年体重增加以及促进肥胖和非肥胖老年人的身体活动可能是预防行动能力丧失和未来残疾的有效策略。
