Goldmann Wilfred
Roslin Institute Neuropathogenesis Unit, West Mains Road, Edinburgh EH 93JF, UK.
Vet Res. 2008 Jul-Aug;39(4):30. doi: 10.1051/vetres:2008010. Epub 2008 Feb 15.
Scrapie, bovine spongiform encephalopathy (BSE), and chronic wasting disease (CWD) are prion diseases in ruminants with considerable impact on animal health and welfare. They can also pose a risk to human health and control is therefore an important issue. Prion protein (PrP) genetics may be used to control and eventually eradicate animal prion diseases. The PrP gene in sheep and other representatives of the order Artiodactyles has many polymorphisms of which several are crucial determinants of susceptibility to prion diseases, also known as transmissible spongiform encephalopathies (TSE). This review will present the current understanding of PrP genetics in ruminants highlighting similarity and difference between the species in the context of TSE.
羊瘙痒病、牛海绵状脑病（BSE）和慢性消耗病（CWD）是反刍动物的朊病毒病，对动物健康和福利有相当大的影响。它们也可能对人类健康构成风险，因此控制是一个重要问题。朊病毒蛋白（PrP）遗传学可用于控制并最终根除动物朊病毒病。绵羊和偶蹄目其他代表动物的PrP基因有许多多态性，其中一些是对朊病毒病（也称为传染性海绵状脑病，TSE）易感性的关键决定因素。本综述将介绍目前对反刍动物PrP遗传学的理解，突出在TSE背景下不同物种之间的异同。
