对绵羊感染羊瘙痒病和牛海绵状脑病的易感性具有保护作用的朊病毒蛋白等位基因。
Prion protein alleles showing a protective effect on the susceptibility of sheep to scrapie and bovine spongiform encephalopathy.
作者信息
Vaccari Gabriele, D'Agostino Claudia, Nonno Romolo, Rosone Francesca, Conte Michela, Di Bari Michele Angelo, Chiappini Barbara, Esposito Elena, De Grossi Luigi, Giordani Francesco, Marcon Stefano, Morelli Luisella, Borroni Renata, Agrimi Umberto
机构信息
Istituto Superiore di Sanità, Department of Food Safety and Veterinary Public Health, Viale Regina Elena 299, 00161 Rome, Italy.
出版信息
J Virol. 2007 Jul;81(13):7306-9. doi: 10.1128/JVI.02880-06. Epub 2007 Apr 18.
Abstract
The susceptibility of sheep to classical scrapie and bovine spongiform encephalopathy (BSE) is mainly influenced by prion protein (PrP) polymorphisms A136V, R154H, and Q171R, with the ARR allele associated with significantly decreased susceptibility. Here we report the protective effect of the amino acid substitution M137T, I142K, or N176K on the ARQ allele in sheep experimentally challenged with either scrapie or BSE. Such observations suggest the existence of additional PrP alleles that significantly decrease the susceptibility of sheep to transmissible spongiform encephalopathies, which may have important implications for disease eradication strategies.
摘要
绵羊对经典羊瘙痒病和牛海绵状脑病（BSE）的易感性主要受朊病毒蛋白（PrP）多态性A136V、R154H和Q171R的影响，其中ARR等位基因与易感性显著降低相关。在此，我们报告了氨基酸替代M137T、I142K或N176K对经羊瘙痒病或BSE实验性攻击的绵羊中ARQ等位基因的保护作用。这些观察结果表明存在其他显著降低绵羊对传染性海绵状脑病易感性的PrP等位基因，这可能对疾病根除策略具有重要意义。
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