B-N-acetyl hexosaminidase (B-NAH) serum levels after endotoxin administration into the portal vein in the rat.

作者信息

Scapa E, Orda R, Neuman M, Sayfan J, Abramovici J, Eshchar J

机构信息

Department of Gastroenterology, Assaf Harofeh Medical Center, Affiliated to Sackler School of Medicine, Tel Aviv University, Israel.

出版信息

Liver. 1991 Feb;11(1):39-41. doi: 10.1111/j.1600-0676.1991.tb00488.x.

DOI:10.1111/j.1600-0676.1991.tb00488.x

PMID:1828523

Abstract

Endotoxin was injected directly into the portal vein in rats with and without common bile duct (CBD) ligation. B-N-acetyl hexosaminidase (B-NAH) activity levels in the serum were found to be significantly elevated 24 h later in both groups. Serum bile acid levels were found to be significantly higher in the endotoxin-injected groups of rats compared to controls. Thus, endotoxin, as well as bile acids, may cause damage to Kupffer cell membranes, resulting in accumulation of B-NAH in rat serum.

摘要