Silber S J, DeRosa M, Pineda J, Lenahan K, Grenia D, Gorman K, Gosden R G
Infertility Center of St. Louis, 224 South Woods Mill Road St. Louis, 63017 MO, USA.
Hum Reprod. 2008 Jul;23(7):1531-7. doi: 10.1093/humrep/den032. Epub 2008 Feb 18.
A series of monozygotic (MZ) twin pairs discordant for premature ovarian failure presented an unusual opportunity to study ovarian transplantation.
Ten MZ twin pairs requested ovarian transplantation and eight have undergone transplantation with cryopreservation of spare tissue. Seven had a fresh cortical tissue transplant, one of whom received a second frozen-thawed transplant after the first ceased functioning at three years. One had a fresh microvascular transplant.
All recipients reinitiated ovulatory menstrual cycles and normal Day 3 serum FSH levels by 77-142 days. Six have already conceived naturally (one twice). Currently, two healthy babies have been delivered, and another three pregnancies are ongoing. The oldest transplant functioned for 36 months, resulting in one child and one miscarriage. She conceived again after a frozen-thawed secondary transplant. There was no apparent difference in return of ovarian function between the eight fresh ovarian grafts and the one frozen graft.
Ovarian transplantation appears to restore ovulatory function robustly. Successful pregnancies, including one after cryopreservation, bode well for application to fertility preservation.
一系列单卵双胞胎中一方患有卵巢早衰而另一方未患病的情况，为研究卵巢移植提供了一个特殊机会。
十对单卵双胞胎要求进行卵巢移植，其中八对已接受移植并对备用组织进行了冷冻保存。七对接受了新鲜皮质组织移植，其中一人在三年后首次移植停止功能后接受了第二次冻融移植。一人接受了新鲜微血管移植。
所有受者在77 - 142天内重新开始排卵性月经周期，且第3天血清促卵泡生成素水平恢复正常。六人已自然受孕（一人两次）。目前，已有两名健康婴儿出生，另有三例妊娠仍在继续。最久的移植发挥功能达36个月，产下一名婴儿并有一次流产。她在进行冻融二次移植后再次受孕。八次新鲜卵巢移植与一次冷冻移植在卵巢功能恢复方面无明显差异。
卵巢移植似乎能有力地恢复排卵功能。成功妊娠，包括一次冷冻保存后的妊娠，预示着其在生育力保存方面的应用前景良好。
