Poizot-Martin I, Lafeuillade A, Dhiver C, Xeri L, Bouabdallah R, Gamby T, Gastaut J A
Hôpital de jour du CISIH, Hôpital Salvator, Marseille.
Presse Med. 1991 Apr 13;20(14):632-6.
Four cases of pigmentation of the skin and mucous membranes in homosexuals of the IVC1 group (CDC classification) are reported. The aetiological investigation, although incomplete, pointed to a medicinal origin which could not be formally confirmed. The drugs suspected were azidothymidine, pyrimethamine and ketoconazole. There was no clinical or laboratory evidence of adrenal insufficiency. The few published cases of cutaneo-mucosal pigmentation in HIV infection, often mimicking adrenal insufficiency, emphasize the need for thorough toxicological investigation; this may avoid prescribing an unnecessary and dangerous corticosteroid therapy which might be harmful in these deeply immunocompromized patients who often have multiple infections.
报告了4例IVC1组（疾病控制与预防中心分类）同性恋者皮肤和黏膜色素沉着的病例。病因调查虽不完整，但指向药物来源，但无法正式确认。怀疑的药物有齐多夫定、乙胺嘧啶和酮康唑。没有肾上腺功能不全的临床或实验室证据。人类免疫缺陷病毒（HIV）感染中少数已发表的皮肤黏膜色素沉着病例，常类似肾上腺功能不全，这强调了进行全面毒理学调查的必要性；这可能避免开具不必要且危险的皮质类固醇疗法，而这种疗法可能对这些免疫严重受损且常伴有多种感染的患者有害。
